We read with great interest the recent publication by Rugge et al ,1 in which the authors conducted a cohort study to evaluate the association between autoimmune gastritis (AIG) and gastric cancer (GC). No excess risk of gastric or other malignancies was observed over a cumulative follow-up time of 10 541 person-years, except for (marginally significant) thyroid cancer (standardised incidence ratio=3.09; 95 % CI 1.001 to 7.20). They concluded that, compared with the general population, corpus-restricted inflammation/atrophy observed in patients with AIG do not increase the risk of GC. The excess GC risk reported in patients with AIG may be influenced by unrecognised previous/current Helicobacter pylori comorbidity. We previously reported 76 GC cases, positive for the antiparietal cell antibody (APCA) test; among them, 8 cases developed cancer in pure AIG stomachs without an apparent history of H. pylori infection.2 Nevertheless, in regions such as Japan, where the H. pylori infection rate is high, the diagnosis of AIG is often difficult because many patients who …

中文翻译：

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根据组织学分析，自身免疫性胃炎可能比幽门螺杆菌相关胃炎更不易患癌症

我们饶有兴趣地阅读了 Rugge 等人最近发表的文章1，其中作者进行了一项队列研究来评估自身免疫性胃炎 (AIG) 与胃癌 (GC) 之间的关联。在 10541 人年的累积随访时间内，没有观察到胃癌或其他恶性肿瘤的额外风险，但甲状腺癌除外（边缘显着）（标准化发病率 = 3.09；95% CI 1.001 至 7.20）。他们的结论是，与一般人群相比，AIG 患者观察到的限制性炎症/萎缩不会增加 GC 的风险。 AIG 患者报告的过度 GC 风险可能受到未识别的既往/当前幽门螺杆菌合并症的影响。我们之前报道了76例GC病例，抗壁细胞抗体（APCA）检测呈阳性；其中，8 例在没有明显 H. pylori 感染史的情况下，在纯 AIG 胃中患上癌症。2 然而，在日本等 H. pylori 感染率较高的地区，AIG 的诊断往往很困难，因为许多患者WHO …