Inflammatory bowel disease (IBD) is a chronic, non-specific, recurrent inflammatory disease, majorly affecting the gastrointestinal tract. Due to its unclear pathogenesis, the current therapeutic strategy for IBD is focused on symptoms alleviation. Autophagy is a lysosome-mediated catabolic process for maintaining cellular homeostasis. Genome-wide association studies and subsequent functional studies have highlighted the critical role of autophagy in IBD via a number of mechanisms, including modulating macrophage function. Macrophages are the gatekeepers of intestinal immune homeostasis, especially involved in regulating inflammation remission and tissue repair. Interestingly, many autophagic proteins and IBD-related genes have been revealed to regulate macrophage function, suggesting that macrophage autophagy is a potentially important process implicated in IBD regulation. Here, we have summarized current understanding of macrophage autophagy function in pathogen and apoptotic cell clearance, inflammation remission and tissue repair regulation in IBD, and discuss how this knowledge can be used as a strategy for IBD treatment.

中文翻译：

---

靶向巨噬细胞自噬用于炎症性肠病的炎症消退和组织修复

炎症性肠病 (IBD) 是一种慢性、非特异性、复发性炎症性疾病，主要影响胃肠道。由于其发病机制尚不明确，目前 IBD 的治疗策略主要集中在缓解症状上。自噬是一种溶酶体介导的分解代谢过程，用于维持细胞稳态。全基因组关联研究和随后的功能研究强调了自噬通过多种机制在 IBD 中的关键作用，包括调节巨噬细胞功能。巨噬细胞是肠道免疫稳态的守门人，特别是参与调节炎症缓解和组织修复。有趣的是，许多自噬蛋白和 IBD 相关基因已被揭示可调节巨噬细胞功能，表明巨噬细胞自噬是一个与 IBD 调节有关的潜在重要过程。在这里，我们总结了目前对巨噬细胞自噬在 IBD 病原体和凋亡细胞清除、炎症缓解和组织修复调节中的作用的理解，并讨论了如何将这些知识用作 IBD 治疗的策略。