Sepsis is a potentially fatal complication of burns and trauma that can cause acute kidney injury (AKI) with substantial morbidity and mortality, but this disease is poorly understood. Despite medical advances, effective therapeutic regimens for septic AKI remain uncommon. MicroRNAs (miRNAs) are endogenous non-coding RNAs that influence the translation of target messenger RNAs in a variety of biological processes. Emerging evidence has shown that miRNAs are intimately associated with septic AKI. The goal of this review was to summarize recent advances in the profound understanding of the functional role of miRNAs in septic AKI, as well as to provide new insights into miRNAs as feasible biomarkers and therapeutic targets for septic AKI.

中文翻译：

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脓毒性急性肾损伤中的 MicroRNA

脓毒症是烧伤和外伤的潜在致命并发症，可导致急性肾损伤 (AKI)，发病率和死亡率很高，但人们对这种疾病知之甚少。尽管医学取得了进步，但针对脓毒性 AKI 的有效治疗方案仍然不常见。微小 RNA (miRNA) 是内源性非编码 RNA，可影响各种生物过程中目标信使 RNA 的翻译。新出现的证据表明，miRNA 与脓毒性 AKI 密切相关。这篇综述的目的是总结最近在深入了解 miRNA 在脓毒症 AKI 中的功能作用方面取得的进展，并为 miRNA 作为脓毒症 AKI 的可行生物标志物和治疗靶点提供新的见解。